The Role of Nerve Growth Factor (NGF) and Glial Cell Line‑Derived Neurotrophic Factor (GDNF) in Tic Disorders
نویسندگان
چکیده
منابع مشابه
The Effect of Endurance Exercise Training on the Expression of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) Genes of the Cerebellum in Diabetic Rat
Objective: Few studies have been conducted on variations of the central nervous system of diabetic patients and much fewer investigations done on the cerebellum of diabetes patients. The current research aims to investigate the effect of endurance training on neurotrophic factors affecting the cerebellum in the diabetic rat. Materials and Methods: This study is experimental.Twenty Wistar rat w...
متن کاملCells of the human optic nerve head express glial cell line-derived neurotrophic factor (GDNF) and the GDNF receptor complex.
PURPOSE Glial cell-line derived neurotrophic factor (GDNF) is a distant member of the TGFbeta family of growth factors and has wide ranging effects within the central nervous system. In the present study we profile the expression of GDNF and its receptor complex (Ret and GFRalpha-1) in cells isolated from the human optic nerve head (ONH). METHODS Lamina cribrosa (LC) cells and ONH astrocytes ...
متن کاملGlial-derived Nerve Growth Factor (gdnf) Mediates Neuronal Phenotypic Changes
Introduction Until recently, chronic nerve compression (CNC) injuries have been relatively understudied. Recent studies have shown that CNC injury induces Schwann cell proliferation and apoptosis with no morphologic evidence of axonal injury (1,2). It has also been shown that the axon undergoes a sprouting response within the zone of compression that is readily apparent by two weeks following i...
متن کاملThe Effects of Progesterone on Glial Cell Line-derived Neurotrophic Factor Secretion from C6 Glioma Cells
Objective(s)Progesterone is a steroid hormone whose biology has been greatly studied within the confines of reproductive function. In recent years, the neuroprotective effects of progesterone have attracted growing interest. Glial cell line-derived neurotrophic factor (GDNF), is a neurotrophic factor which plays a crucial role in the development and maintenance of distinct sets of central and p...
متن کاملThe RET–Glial Cell-derived Neurotrophic Factor (GDNF) Pathway Stimulates Migration and Chemoattraction of Epithelial Cells
Embryonic development requires cell migration in response to positional cues. Yet, how groups of cells recognize and translate positional information into morphogenetic movement remains poorly understood. In the developing kidney, the ureteric bud epithelium grows from the nephric duct towards a group of posterior intermediate mesodermal cells, the metanephric mesenchyme, and induces the format...
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ژورنال
عنوان ژورنال: Pakistan Journal of Medical Sciences
سال: 2018
ISSN: 1681-715X
DOI: 10.12669/pjms.344.15555